Publications

Articles in Refereed Journals

1)         Bondu, V., Wu, C., Cao, W., Simons, P., Gillette, J., Zhu, J., Erb, L., Zhang, X.* and Buranda,    T.* (2017): Low affinity binding in cis to P2Y2R mediates force-dependent integrin activation during hantavirus infection. Molecular Biology of the Cell (Published online before print August 23, 2017, doi: 10.1091/mbc.E17-01-0082)

2)         Dragovich, M.A., Genemaras, K., Dailey HL, Jedlicka S, and Zhang, X.* (2017): Dual     regulation of L-selectin-mediated leukocyte-endothelial adhesion by endothelial surface glycocalyx. Cellular and Molecular Bioengineering 10(1):102-113.

3)         Guo, X.D., Yan, C., Shi, X., Huang, M., Huang, W., Wang, Y., Pan, W., Cai, M., Li, L., Wu, W., Bai, Y., Zhang, C., Liu, Z., Wang, X., Zhang, X., Tang, C., Wang, H., Liu, W., Ouyang, B., Wong, C.C., Chou, J.J., Cao, Y., Xu, C. (2017): Lipid-dependent conformational dynamics underlie the functional versatility of T-cell receptor. Cell Research 27(4):505-525.

4)         Song, J.W., Zullo, J.A., Liveris, D., Dragovich, M., Zhang X., and Goligorsky, M.S. (2017): Therapeutic Restoration of Endothelial Glycocalyx in Sepsis. The Journal of pharmacology and experimental therapeutics. 361(1):115-121.

5)         Song, J.W., Zullo, J.A., Lipphardt, M., Dragovich, M., Zhang X., Fu, B. and Goligorsky, M.. (2017): Endothelial Glycocalyx – the battleground for complications of sepsis and kidney injury. Nephrology Dialysis Transplantation. Epub ahead of print.

6)         Deng, W., Xu, Y., Chen, W., Paul, D.S., Syed, A.K., Dragovich, M.A., Liang, X., Zakas, P., Berndt, M.C., DiPaola, J., Ware, J., Lanza, F., Doering, C.B., Bergmeier, W., Zhang, X., & Li, R. (2016): Platelet clearance via shear-induced unfolding of the mechanosensory domain in glycoprotein Ib-IX complex. Nature Communications 7: 12863.

7)         Dragovich, M.A., Chester, D., Fu, B., Goligorsky, M.S., and Zhang. X.* (2016): Mechanotransduction of endothelial glycocalyx mediates nitric oxide production by activation of TRP channels. AJP – Cell Physiology 311(6):C846-853.

8)         LeBlon, C.E, Fodor, C. R., Zhang, T., Zhang, X., and Jedlicka, S.S (2015): Correlation between in vitro expansion-related cell stiffening and differentiation potential of human mesenchymal stem cells. Differentiation 90 (1), 1-15. 9)         Zhang, W., Deng, W., Zhou, L., Xu, Y., Yang, W., Liang, X., Wang, Y., Kulman, J.D., Zhang, X.* & Li, R.* (2015): Identification of a juxtamembrane mechano-sensitive domain in the platelet mechanosensor glycoprotein Ib-IX complex. Blood, 125:562-569. (Featured paper, comments see Ruggeri, E.M. “Platelet GPIb: sensing force and responding”, Blood, 125:423-424.)

10)       Fu, X. Xu, Y., Wu, C., Moy, V.T., and Zhang, X.* (2015): Anchorage-dependent binding of integrin I-domain to adhesion ligands. Journal of Molecular Recognition, 28:385-92.

11)       Ouyang, Y., Wei, W., Cheng X., Zhang, X., Webb, E.B. III, and Oztekin, A. (2015): Flow-induced conformational change of von Willebrand Factor multimer. Journal of Non-Newtonian Fluid Mechanics, 217:58-67.

12)       Zhang, W., Deng, W., Wang, Y., Zhou, L., Yang, W., Linag, X., Cho, S., Kulman, J.D., Zhang, X. & Li, R. (2014): Identification of the mechanosensory domain in the platelet mechanosensor GPIb-IX complex. Journal of Thrombosis and Haemostasis, 12: 74-75.

13)       Wang, Y.Z., Chen, L., Wang, H.Y., Zhang, X., Fu, J., Xiong, X.M., and Zhang, J.X. (2014): Development of “fragility” in relaxor ferroelectrics. Journal of Applied Physics 115, 054106.

14)       Cao, Y., Hoeppner, L.H., Bach, S., Guangqi, E., Guo, Y., Wang, E., Wu, J., Cowley, M.J., Chang, D.K., Waddell, N., Grimmond, S.M., Biankin, A.V., Daly, R.J., Zhang, X., and Mukhopadhyay, D. (2013): Neuropilin-2 promotes extravasation and metastasis by interacting with endothelial a5 integrin. Cancer Research 73(14):4579-4590.

15)       Wang, Y.Z., Zhang, X.*, and Zhang, J.X. (2013): A “configurational entropy-loss” law for non-Arrhenius relaxation in disordered systems. Journal of Applied Physics 113, 194105

16)       Wang, Y.Z., Zhang, X., and Zhang, J.X. (2013): New insight into the kinetic behavior of the structural formation process in agar gelation. Rheologica Acta 52:39–48

17)       Przybylowski, C., Quinn, T., Callahan, A., Kaplan, M., Golding, A., Alesi, C., Ammar, M., LeBlon, C.E, Guo, Y., Zhang, X., and Jedlicka, S.S (2012): MC3T3 Preosteoblast Differentiation on Bone Morphogenetic Protein-2 Peptide Ormosils. The Journal of Materials Chemistry 22: 10672-10683.

18)       Hu, L., Fan, Z., Du, H., Ni, R., Zhang, S., Yin, K., Ye, J., Zhang, Y., Wei, X., Zhang, X., Gross, P. L., Kunapuli, S. P., and Ding, Z. (2011): BF061, a novel antiplatelet and antithrombotic agent targeting P2Y12 receptor and phosphodiesterase. Thrombosis and Haemostasis 106: 1203-14.

19)       Zhang, S., Hu, L., Yu, X., Guo, Y., Zhang, Y., Niu, H., Jin, J., Bhavaraju, K., Du, H., Liu, J., Zhang, X., Kunapuli, S. P., and Ding, Z. (2010): BF0801, a novel adenine derivative, inhibits platelet activation via PDE inhibition and P2Y12 antagonism. Thrombosis and Haemostasis, 104: 845-57.

20)       Du, D., Xu, F., Yu, L., Bao, H., Zhang, C., Lu, X., Yuan, H., Zhu, X., Zhang, X., and Chen, Z. (2010): The tight Junction protein, occludin, regulates the directional migration of epithelial cells. Developmental Cell, 18: 52-63.

21)       Kim, J., Zhang, C.-Z., Zhang, X., and Springer, T.A (2010): A mechanically stabilized receptor-ligand flex-bond important in the vasculature. Nature, 466: 992-5.

22)       Zhang, X., Halvorsen, K., Zhang, C.Z., Wong, W.P. and Springer, T.A (2009): Mechanoenzymatic cleavage of the ultralarge vascular protein, von Willebrand Factor. Science, 324:1330-1334. (Cited over 300 times. Featured paper, comments see Gebhardt, J. C. and Rief, M. “Force Signaling in Biology”, Science, 324:1278-1280.)

23)       Zhang, Q., Zhou, Y., Zhang, C.Z., Zhang, X., Lu, C., and Springer, T.A (2009): Structural specializations of A2, a force-sensing domain in the ultralarge vascular protein von Willebrand factor. PNAS 106(23):9226-31.

24)       Zhang, X.*, Wojcikiewicz, E., and Moy, V.T (2006): Dynamic adhesion of T-lymphocytes to endothelial cells revealed by atomic force microscopy. Experimental Biology and Medicine, 231: 1306-12.

25)       Wojcikiewicz, E., Abdulreda, M.H., Zhang, X. and Moy, V.T (2006): Force spectroscopy of LFA-1 and its ligands, ICAM-1 and ICAM-2. Biomacromolecules, 7:3188-3195.

26)       Zhang, X., Craig, S.E., Kirby, H., Humphries, M.J. and Moy, V.T. (2004): Molecule basis for the dynamic strength of the integrin a4b1/VCAM-1 interaction. Biophysical Journal, 87: 3470-3478.

27)       Zhang, X., Chen, A., DeLeon, D., Li, H., Noiri, E., Moy, V.T. and Goligorsky, M.S.  (2004): Atomic force microscopy measurement of leukocyte-endothelial interaction. American Journal of Physiology-Heart and Circulatory Physiology, 286: H359-367.

28)       Zhang, X., Bogorin D.F., and Moy, V.T. (2004): Molecular basis of the dynamic strength of the sialyl Lewis x – selectin Interaction. ChemPhysChem, 4:100-107.

29)       Wojcikiewicz, E., Zhang, X., and Moy, V.T. (2004). Force and compliance measurements on living cells using atomic force microscopy. Biological Procedures Online, 6:1-9.

30)       Zhang, X. and Moy, V.T. (2004): Intermolecular forces of leukocyte adhesion molecules. Microscopy and Microanalysis 10:1422-1423.

31)       Zhang, X.* and Moy, V.T. (2003): Cooperative adhesion of ligand-receptor bonds. Biophysical Chemistry, 104:271-278.

32)       Wojcikiewicz, E., Zhang, X., and Moy, V.T. (2003): Contributions of molecular binding events and cellular compliance to the modulation of leukocyte adhesion. Journal of Cell Science, 116:2531-2539.

33)       Zhang, X., Wojcikiewicz, E., and Moy, V.T. (2002): Force spectroscopy of the Leukocyte Function-Associated Antigen-1 (LFA-1)/Intercellular Adhesion Molecule-1 (ICAM-1) interaction. Biophysical Journal, 83:2270-2279.

34)       Micic, M., Zheng, Y., Moy, V.T., Zhang, X., Andreanopolous, F, Hua, F.Q. and Leblanc,R.M. (2002): Comparative studies of surface topography and mechanical properties of a novel photoswitchable, biocompatable PEG-NC based hydrogel. Colloids and Surfaces B: Biointerface, 27:147-158.

35)       Zhang, X., Wojcikiewicz, E., and Moy, V.T. (2002). Probing single ICAM-1/LFA-1 interactions under external forces. ScientificWorldJournal, 2:41-42.

36)       Lui, S.L., Chan, L.Y.Y., Zhang, X., Zhu, W., Chan, T.M., Fung, P.C.W. and Lai, K.N. (2001): Effect of mycophenolate mofetil on nitric oxide production and inducible nitric oxide synthase gene expression during renal ischaemia-reperfusion injury. Nephrology, Dialysis, Transplantation, 16:1577-1582.

37)       Zhang, X., Li, H., Jin, H., Ebin, Z., Brodsky, S., and Goligorsky, M.S. (2000): Effects of homocysteine on endothelial nitric oxide production. American Journal of Physiology-Renal Physiology, 279:F671-678.

38)       Ge, Z.D., Zhang, X., Fung, P.C.W. and He, G.W. (2000): Endothelium-dependent hyperpolarization under relaxation resistant to N(G)-nitro-L-arginine (L-NNA) and indomethacin in coronary micro-arteries. Cardiovascular Research, 46:547-556.

39)       Kuang, Z.Q., Zhang, J.X., Zhang, X., Liang, K.F., and Fung, P.C.W. (2000): Kinetic parameters in the thermoelastic martensitic transformation of Co. Solid State Communications, 14:231-235.

40)       Kuang, Z.Q., Zhang, J.X., Zhang, X., Liang, K.F. and Fung, P.C.W. (2000): Scaling behaviours in the thermoelastic martensitic transformation of Co. Scripta Materialia, 42:795-799.

41)       Chan, K.L., Zhang, X., Fung, P.C.W, Guo, W.H., and Tam, P.K.H. (1999): Role of nitric oxide in intestinal ischaemia-reperfusion injury studied using electron paramagnetic resonance. British Journal of Surgery, 86:1427-1432.

42)       Lui, S.L., Zhang, X., Zhu, W., Lo, C.Y., Chan, T.M., Fung, C.W., and Lai, K.N. (1999): Demonstration of nitric oxide generation during renal ischemia-reperfusion injury. Transplantation Proceedings, 3:1020-1021.

Submitted Manuscripts

1)         Xu, Y., McKinnon, T.A.J., Zhang, W., Golding, A., Wu, C., Cheng, X., Oztekin, A., Webb, E.B., and Zhang, X.* (2017): Biomechanical characterization of von Willebrand Factor-collagen interactions. Biophysical Journal (in revision).

2)         Quach, M.E., Dragovich, M.A., Chen, W., Syed, A.K., Cao, W., Liang, X., Deng, W., De Meyer, S., Zhu, G., Ni, He., Ware, J., Deckmyn, H., Zhang, X., & Li, R. (2017): Fc-independent immune thrombocytopenia via mechanomolecular signaling in platelets. Blood (in revision).

3)         Wang, Y., Chen, W., Zhang, W., Casari, C., Druzak, S.A., Ware, J., Berndt, M.C., Lanza, F., Bergmeier, W., Zhang, X., & Li, R. (2017): Desialylation of O-glycans on glycoprotein Ibα drives receptor signaling and platelet clearance. Blood Advances (in revision).

4)         Zhang, X., Song, J.W., Lipphardt, M., Goligorsky, M.S. (2017): Endothelial cell dysfunction and glycocalyx – the vicious circle. American Journal of Pathology (in revision).

5)         Wei, W., Cheng, X., Zhang, X., Oztekin, A., and Webb, E.B. (2017): Characteristics of von Willebrand Factor adhesion on collagen surface under flow. Biophysical Journal (in revision).

6)         Sgarlato, A., Bornhorst, K., Genemaras, K., Vojir, K., and Zhang, X* (2017): Biophysical mechanism of leukocyte adhesion to stainless steel. (Submitted)

7)         Dragovich, M.A., Fortoul, N., Jagota, A., Schutt, K., Xu, Y., Sanabria, M., Moller-Tank, S., Maury, W., and Zhang. X.* (2017): Biomechanical characterization of TIM protein-mediated Ebola virus-host cell adhesion (submitted).

Book Chapters

1)         Rico, F., Zhang, X. and Moy, V.T. (2011): Probing cellular adhesion at the single molecular level. Chapter 11 (p. 225-262) in Life at the Nanoscale: Atomic Force Microscopy of Live Cells (Yves Dufrêne, Ed.) Pan Stanford Publishing Ltd.

2)         Zhang, X.*, Rico F., Xu, A.J. and Moy, V.T. (2009): Atomic force microscopy of protein-protein interactions. Chapter 19 in Handbook of Single-Molecule Biophysics (Peter Hinterdorfer and Antoine van Oijen, Ed. ISBN: 978-0-387-76496-2), Springer Press ((http://www.springerlink.com/content/q85x87x114735130/)

3)        Zhang, X. and Moy, V.T. (2006): Intermolecular forces of leukocyte adhesion molecules. Chapter 9 (p.159-168) in Force Microscopy: Application in Biology and Medicine (Bhanu P. Jena and Johann Karl H. Horber, Ed.), John Wiley & Sons Inc. Press.

4)        Zhang, X., Wojcikiewicz, E., Abdulreda, M., Chen, A., and Moy, V.T. (2005): Probing ligand-receptor interactions with atomic force microscopy. Chapter 21 (p.399-413) in Protein-Protein Interactions: A Molecular Cloning Manual, 2nd Edition (Erica A. Golemis and Peter D. Adams, Ed.), Cold Spring Harbor Laboratory Press.

5)        Zhang, X., Chen, A., Wojcikiewicz, E., and Moy, V.T. (2002): Probing ligand-receptor interactions with atomic force microscopy. Chapter 13 (p.241-254) in Protein-Protein Interactions: A Molecular Cloning Manual (Erica A. Golemis, Ed.), Cold Spring Harbor Laboratory Press.

Published reports and conference proceedings (all listed are refereed)

1)         McKinnon, T., O’Donnel, J., Laffan, M., Jenkins, V. and Zhang, X. (2017): Characterisation of Q1541R, a Novel von Willebrand Factor Variant Causing Type 2A von Willebrand Disease – ADAMTS13 Cleavage of Type 2A Variants under Shear Stress. Journal of Thrombosis and Haemostasis 15, in press.

2)         Doerr, A., Obrien, H., Laffan, M., Henne, P., Shapiro, S., Zhang, X. and McKinnon, T. (2017): Von Willebrand Factor Free-thiols Are Critical for Function under High Shear Stress. Journal of Thrombosis and Haemostasis 15, in press.

3)         Lai, W., Cao, W., Wang, Y., Cheng, X. and Zhang, X. (2017): Exploring the Mechanical Properties of Mutants of vonWillebrand Factor. Archives of BMES2017, BMES2017-002459.

4)         Wang, Y., Zhang, W., Lai, W., Cheng, X. and Zhang, X. (2017): Unfolding Behavior of Von Willebrand Factor (VWF) Multimer and Fragments. Archives of BMES2017, BMES2017-001226.

5)         Zhang, X., Dragovich, M., Chester, D., Fu, B. (2017): Mechanotransduction of the endothelial glycocalyx mediates nitric oxide production through activation of TRP channels. The FASEB Journal 31, 837.21-837.21.

6)         Zhang, X., Xu, Y., Mckinnon, T.M.J., and Zhang, W. (2017): Biophysical mechanism of von Willebrand Factor-collagen interactions. Biophysical Journal, 112, 3, 455a

7)         Dragovich, D., Xu, Y., Schutt, K., Sanabria, M., Zhang, X. (2016):  An Atomic Force Microscopy Study of Ebola Virus Host Cell Interaction. Archives of BMES2016, BMES2016-000253

8)         Dragovich, M.A., Chester, D., and Zhang. X.* (2016): Mechanotransduction of endothelial glycocalyx mediates nitric oxide production through activation of TRP channels. Biophysical Journal, 110, 3, 23a.

9)         Zhang, X., Zhang, W., Dragovich, M.A., Deng, W., & Li, R. (2016): Biophysical Characterization of Mechanosensors within the Plasma Protein von Willebrand Factor and its Receptor Platelet Glycoprotein Ib-IX. Biophysical Journal, 110, 3, 637a

10)       Dragovich, M.A., Genemaras, K., and Zhang, X. (2015): Biomechanical Characterization of Glycocalyx Mediated Leukocyte Adhesion. Archives of BMES 2015 BMES2015-000812.

11)       Dragovich, M.A., Chester, D. and Zhang, X. (2015): Single-cell Characterization of Endothelial Glycocalyx Mediated Nitric Oxide Production. Archives of BMES 2015, BMES2015-000653.

12)       Moyer, D., Xu, Y., Dragovich, M.A., Schutt, K., and Zhang. X.* (2015): Biophysical mechanisms of Ebola virus-host cell interaction.  Archives of BMES2015, BMES2015-002988.

13)       Chester, D., Dragovich, M.A., Fu, B., and Zhang, X (2014): Endothelial Surface Glycocalyx Stimulation Induced Nitric Oxide and Calcium Signaling, Archives of BMES 2014, BMES2014-002739.

14)       Zhang, X. (2012): Biophysical Mechanisms of Human Integrin α4β7 -Mediated Leukocyte Rolling and Firm Adhesion, Recent advances in mechanobiology (Proceeding of the International Symposium on Mechanobiology, Shanghai, China, November, 2011), Shanghai Science and Technology Press Co

15)       Zhang, X. (2012): Probing the biomechanical properties of single protein molecules, Recent advances in mechanobiology (Proceeding of the International Symposium on Mechanobiology, Shanghai, China, November, 2011), Shanghai Science and Technology Press Co

16)       Sgarlato, A., Guo, Y., Vojir, K., and Zhang, X. (2012): Leukocyte-medical stainless Steel Adhesion Revealed by Single-cell Force Spectroscopy. Archives of BMES 2012.

17)       Zhang, X. (2011): Optical Manipulation and Mechanical Characterization of Individual Biomolecules, Proceeding of IEEE International Conference on Micro/Nano Optical Engineering, Changchun, China, June, 2011

18)       Zhang, X. (2011): The Biophysical Mechanisms of Integrin-mediated Leukocyte Adhesion, Proceeding of the 34th Annual Meeting of the Adhesion Society, Savannah, GA, February, 2011

19)       Zhang, X. (2009): Optical Manipulation and Structural Dynamics Measurement of Individual Protein Molecules, Proceeding of the 2009 International Conference on Optical Instrument and Technology (OIT’09), Shanghai, China, September, 2009.

20)       Zhang, X. (2009): Probing the structural dynamics of individual protein molecules, Proceeing of International Conference on Nanoscience and Technology, Beijing, China, September, 2009.

21)       Zhang, X. (2008): Protein structural dynamics probed by single-molecule optical tweezers , Proceeding of the first Chinese National Conference of Optical Tweezer Technology, Hefei, China, November, 2008.

22)       Zhang, X. (2008): Protein biomechanical properties. Prodeeding of the 6th Chinese National Conference of Liquid and Soft Material, Hefei, China, November, 2008.

23)       Zhang, X., Halvorsen, K., Zhang, C.Z., Wong, W.P. and Springer, T.A (2009): Unfolding, refolding and proteolysis of the von Willebrand Factor A2 domain under tensile force. Biophysical Journal, 96(3): 37a.

24)       Seog, J., Dill, J., Zhang, X., Cecconi, C., Kim, M., Shimaoka, M., Bustamante, C., and Springer, T. A. (2007): Unfolding behavior of Rossmann fold integrin I domain measured directly using optical tweezer. Abstracts of Papers of the American Chemical Society.

25)       Zhang, X. and Moy, V.T. (2004): Atomic force microscopy measurements of monocyte-endothelial interaction. FASEB Journal, 18 (5): A387.

26)       Zhang, X. and Moy, V.T. (2004): Mechanism by which leukocyte adhesion complexes resist external forces. FASEB Journal, 18 (5): A633.

27)       Zhang, X., Craig, S.E., Humphries, M.J. and Moy, V.T. (2004): Structural basis for the dynamic strength of the integrin alpha 4 beta 1/VCAM-1 interaction. FASEB Journal, 18 (5): A1197-A1198.

28)       Zhang, X., Chen, A., DeLeon, D., Li, H., Noiri, E., Elitok, E., Moy, V.T. and Goligorsky, M.S.  (2003): Atomic Force Microscopy Measurement of Leukocyte-Endothelial Interaction: Inhibition by RGD Peptide. Journal of American Society of Nephrology, 14: SA-FC208.

29)       Zhang, X. and Moy, V.T. (2003): How do leukocyte adhesion molecules resist external forces? Biophysical Journal, 84 (2): 332a.

30)       Zhang, X. and Moy, V.T. (2003): Single molecule force spectroscopy of the integrin LFA-1/ICAM-1 interaction. Biophysical Journal, 84 (2): 122a.

31)       Wojcikiewicz, E., Zhang, X. and Moy, V.T. (2003): Contributions of molecular binding events and cellular compliance to the modulation of leukocyte adhesion. Miami Nature Biotechnology Short Reports, 14:76.

32)       Zhang, X. and Moy, V.T. (2002): Single molecule force spectrum of the integrin LFA-1/ICAM-1 complex.  Molecular Biology of the Cell, 13:347a.

33)       Zhang, X., Wojcikiewicz, E., and Moy, V.T. (2002): Single ICAM-1/LFA-1 interaction under external force. Miami Nature Biotechnology Short Reports, 13:21.

34)       Zhang, X., and Moy, V.T. (2001): Enhanced cooperativity among ligand-receptor bonds results from increases in retraction rate during force-induced dissociation. Biophysical Journal, 80 (1): 655.45 Part 2.

35)       Zhang, X., Wojcikiewicz, E., and Moy, V.T. (2001): Probing the interaction between leukocyte function-associated antigen-1 (LFA-1) and intercellular adhesion molecule-1 (ICAM-1) by cell-cell de-adhesion force spectroscopy. Biophysical Journal, 80 (1): 655.46 Part 2.

36)       Zhang, X. and Kerrick, W.G. (2001): Measurement of intracellular nitric oxide in rat aorta using fluorescent indicator 4,5-Diaminofluorescein-2 (DAF-2). FASEB J, 15 (5):A772.

37)       Zhang, X., Wojcikiewicz, E. and Moy, V.T. (2000): Discrete interactions in lymphocyte adhesion measured by single-molecule force spectroscopy. The 40th ASCB Annual Meeting Late Abstract, L25.

38)       Zhang, X., and Moy, V.T. (2000): Cooperative adhesion among ligand-receptor bonds. The 40th ASCB Annual Meeting Achieve, L24.

39)       Zhang, X., Ebin, Z. and Goligorsky, M.S. (1999): Effects of homocysteine on endothelial nitric oxide Production. Journal of American Society of Nephrology, 10:401A.

40)       Lui, S.L., Zhang, X., Chan, L., Zhu, W., Chan, T.M., Fung, C.W. and Lai, K.N. (1999): Mycophenolate Mofetil inhibits nitric oxide generation during renal ischemia-reperfusion injury. Transplantation, 67(7):S37.

41)       Zhang, X. (1999): Analysis of nitric oxide generation in various organs of animal models during ischemia-reperfusion. The University of Hong Kong Thesis Online.

42)       Zhang, X., Fung, P.C.W., Zhu, W., Lui, S.L., Chan, K.L. and Cho, C.H. (1998): Factors affecting nitric oxide production in the renal ischemia-reperfusion injury. Nitric Oxide Biology and Chemistry, 2(2):131.

43)       Zhu, W., Zhang, X., Zhao, B.L., Fung, P.C.W., Lam, S.K. and Cho, C.H. (1998): Green tea polyphenols may protect carbon tetrachloride-induced liver injury by regulation of nitric oxide level in liver. Nitric Oxide Biology and Chemistry, 2(2):117.

44)       Wen, Z.F., Cho, C.H., Zhu, W., Zhang, X., Ma, L., Lai, K.C., Hui, W.M., Fung, P.C.W. and Lam, S.K. (1998): Is inducible nitric oxide synthase (iNOS) involved in the pathogenesis of indomethacin-induced intestinal damage? Gastroenterology, 114 (4):A329.