Research

Major Research Interests

Single-molecule nanomechanics: we employ single-molecule atomic force microscopy and optical tweezer approaches to acquire quantitative measurements of protein conformation and protein-protein interactions. 

Our research focuses on three aspects:

  1. Interfaces between biopolymers and circulatory flow
  2. Cellular mechanosensing and mechanotransduction
    • Platelet mechanosensing and activation
    • Endothelial mechanosensing and mechanotransduction
  3. Mechanobiology of intercellular interactions
    • Lymphocyte adhesion mediated by integrins
    • Virushost cell interaction

Ongoing research funding

  1. NIH/1R01DA043567, 4/1/2018-2/28/2023, “Prototoxin effects on nicotinic receptor function”, Role: Co-investigator
  2. NIH/1R15AI133634, 1/16/2018-12/31/2020,  “Biomechanics of TIM Protein-Mediated Ebola Virus-Host Cell Adhesion” Role: PI
  3. NSF/DMS-1463234, 9/15/2015-8/31/2018, “Mechano-Biologically Informed Molecular Models of Flow Sensitive Biopolymers”, Role: Co-PI
  4. NIH/5R01HL082808, 7/1/2015-6/30/2019, “Structure and function of platelet glycoprotein Ib-IX-V complex”, Role: Co-investigator