Publications

  1. Osickova, A., Masin, J., Sulc, M. Roderova, J., Wald, T., Brown, A.C., Koufos, E., Chang, E.H., Giannakakis, A., Lally, E.T., Balashova, N., and Osicka, R. Cytotoxic activity of Kingella kingae RtxA toxin depends on post-translational acylation of lysine residues and cholesterol binding. Emerging Microbes and Infections. In press.
  2. Nygren, P., Balashova, N.V., Brown, A.C., Kieba, I., Dhingra, A., Boesze-Battaglia, K., and Lally, E.T. Aggregatibacter actinomycetemcomitans leukotoxin blocks inside-out activation of LFA-1. Cellular Microbiology. In press.
  3. Brown, A.C., Boesze-Battaglia, K., Balashova, N., Gomez, N.M., Speicher, K., Tang, H.-Y., Duszyk, M.E., and Lally, E.T. Membrane localization of the repeats-in-toxin (RTX) leukotoxin (LtxA) produced by Aggregatibacter actinomycetemcomitans. PLOS ONE. In press.
  4. Nice, J.B.D, Balashova, N.V., Kachlany, S.C., Koufos, E., Krueger, E., Lally, E.T., and Brown, A.C. Aggregatibacter actinomycetemcomitans leukotoxin is delivered to host cells in an LFA-1-independent manner when associated with outer membrane vesicles. Toxins. In press.
  5. Krueger, E., Hayes, S., Chang, E.H., Yutuc, S., and Brown, A.C. Receptor-based Peptides for Inhibition of Leukotoxin Activity.  ACS Infectious Diseases.  4(7):1073-1081.
  6. Balashova, N., Giannakakis A., Brown, A.C., Koufos, E., Arakawa, T., Tang, H.-Y., and Lally, E.T. 2018. Purification and characterization of recombinant leukotoxin from Aggregatibacter actinomycetemcomitans produced in Escherichia coli expression system. Gene. 672:106-114.
  7. Rasti, E.R.D, Schappert, M.S., and Brown, A.C. Association of Vibrio cholerae 569B outer membrane vesicles with host cells occurs in a GM1-independent manner. Cellular Microbiology.20:e12828.
  8. Koufos, E., Chang, E.H., Rasti, E.S., Krueger, E., and Brown, A.C. Use of a cholesterol recognition amino acid consensus (CRAC) peptide to inhibit binding to cholesterol by a bacterial toxin. Biochemistry. 55(34):4787-4797.
  9. Brown, A.C.ǂ, Koufos, E.ǂ, Balashova, N.V., Boesze-Battaglia, K., and Lally, E.T. Inhibition of LtxA toxicity by blocking cholesterol binding with peptides. Molecular Oral Microbiology. 31(1):94-105. ǂThese authors contributed equally.
  10. Webb, J.N., Koufos, E., and Brown, A.C. Inhibition of Bacterial Toxin Activity by the Nuclear Stain, DRAQ5.  Journal of Membrane Biology.  249(4):503-511.
  11. Miller, C.M., Brown, A.C., and Mittal, J. 2014. Disorder in cholesterol-binding functionality of CRAC peptides: A molecular dynamics study. Phys Chem. B. 118:13169-13174.
  12. Brown, A.C., Balashova, N.V., Epand, R.M., Epand, R.F., Bragin, A. Kachlany, S.C., Walters, M.J., Du, Y., Boesze-Battaglia, K., and Lally, E.T. Aggregatibacter actinomycetemcomitans leukotoxin utilizes a cholesterol recognition amino acid consensus (CRAC) site for membrane association. J. Biol. Chem. 288:23607-23621.
  13. Brown, A.C., and Wrenn, S.P. 2013. Nanoscale phase separation in DSPC-Cholesterol systems. 29:9832-9840.
  14. Walters, M.J.ǂ, Brown, A.C.ǂ, Edrington, T.C., Baranwal, S., Du, Y., Lally, E.T., and Boesze-Battaglia, K. 2013. Membrane association and destabilization by Aggregatibacter actinomycetemcomitans leukotoxin require changes in secondary structures. Oral Microbiol. 28:342-353. ǂ These authors contributed equally.
  15. Brown, A.C., Boesze-Battaglia, K., Du, Y., Stefano, F.P., Kieba, I.R., Epand, R.F., Kakalis, L., Yeagle, P.L., Epand, R.M., and Lally, E.T. 2012. Aggregatibacter actinomycetemcomitans leukotoxin cytotoxicity occurs through bilayer disruption. Microbiol. 14:869-881.
  16. Krummenacher, C., Brown, A.C., Edrington, T., Shenker, B.J., and Boesze-Battaglia, K. 2012. Mechanisms by Which Pathogens Hijack and Utilize Membrane Domains to Mediate Cytotoxicity. In P. Yeagle (Ed.), The Structure of Biological Membranes (Third Edition). CRC Press, Boca Raton, FL.
  17. Fong, K.P.ǂ, Tang, H.-Y.ǂ, Brown, A.C., Kieba, I.R., Speicher, D.W., Boesze-Battaglia, K., and Lally, E.T. 2011. Aggregatibacter actinomycetemcomitans leukotoxin is post-translationally modified by addition of either saturated or hydroxylated fatty acyl chains. Oral Microbiol. 6:1-15. ǂ These authors contributed equally.
  18. Boesze-Battaglia, K., Brown, A.C., Walker, L., Besack, D., Wrenn, S.P., Krummenacher, C., and Shenker, B.J. 2009. Cytolethal distending toxin induced cell cycle arrest of lymphocytes is dependent upon recognition and binding to cholesterol. Biol. Chem. 284:10650-10658.
  19. Brown, A.C., Wrenn, S.P., and Abedin, M.Z. 2009. Gender differences in cholesterol nucleation in bile: Estrogen is a potential contributory factor. Membr. Biol. 232:35-45.
  20. Brown, A.C., Towles, K.B., and Wrenn, S.P. 2007. Measuring raft size as a function of membrane composition in PC-based systems: Part I – Binary systems. Langmuir. 23:11180-11187.
  21. Brown, A.C., Towles, K.B., and Wrenn, S.P. 2007. Measuring raft size as a function of membrane composition in PC-based systems: Part II – Ternary systems. 23:11188-11196.
  22. Towles, K.B., Brown, A.C., and Wrenn, S.P., Dan, N. 2007. Effect of membrane microheterogeneity and domain size on fluorescence resonance energy transfer. J.93:655-667.