As infrastructural systems rapidly grow in scale, complexity and interconnectedness, legacy operations driving the systems have shown to be limited in their ability to handle large-scale disasters that can occur either through natural extreme events, or through carefully orchestrated attacks, and in particular cyber-attacks. Advances in sensing and communication technologies allow diverse data collection at massive scale, granting unprecedented visibility into system operations and provide enormous potential to overhaul the operational paradigms towards increased safety, security and sustainability. It is towards this end that we are conducting data-intensive data-driven research for inference and control in large scale cyber physical infrastructural networks.