BIO NANO INTERFACE LAB

Our primary research interest is Micro/NanoEngineering for Biology and Medicine, in particular, using combined experimental and computational approaches to characterize the interfacial phenomena at the micro/nano scale and in biological systems. Examples include lab on chip devices for biomedical application, fluid-structure interaction, particulate and multiphase flow, blood rheology, biomedical device (artificial heart, valves, stents, etc) design, electromagnetic manipulation of bio-nanoparticles, DNA sequencing in functionalized nanopores, etc. Current efforts focus on two emerging applications of bio-nanotechnology: Nanomedicine and Biosensing which involves microfluidics, multiscale modeling, biofluid mechanics, image-based simulation, MEMS fabrication, 3D printing, nanoparticle adhesion dynamics, and cell manipulation.

LVHN trying cancer blood test developed by Lehigh University professor

Between CT scans in July and December, Stephen Kauffman's kidney cancer went from undetectable to widely spread in his brain, femur, liver, stomach lining and vertebrae. "All of a sudden, it's all over the place," said Kauffman, a Harleysville, Montgomery County resident. Despite advances in...
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Lehigh professor develops blood test for cancer

When it comes to cancer, early detection can be the difference between life and death. Many people, however, don't find out they have cancer until they experience symptoms, and by then it's all the harder to beat. It's an unfortunate chronology that Lehigh University Professor Yaling Liu hopes to...
Read More

Simpler, High-Accuracy Method Detects Rare Circulating Tumor Cells

Metastasis―the development of tumor growth at a secondary site―is responsible for the majority of cancer-related deaths. It occurs when the primary tumor site sheds cancerous cells which are then circulated through the body via blood vessels or lymph nodes. These become seeds for eventual tumor...
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Study demonstrates effectiveness of new, innovative machine learning technique to analyze the presence of rare circulating tumor cells (CTCs) in blood

Metastasis―the development of tumor growth at a secondary site―is responsible for the majority of cancer-related deaths. It occurs when the primary tumor site sheds cancerous cells which are then circulated through the body via blood vessels or lymph nodes. These become seeds for eventual tumor...
Read More

Recent Publications

Quantitative absorption imaging of red blood cells to determine physical and mechanical properties

Authors Ratul Paul, Yuyuan Zhou, Mehdi Nikfar, Meghdad Razizadeh, Yaling Liu Publication date 2020 Journal RSC Advances Volume 10 Issue 64 Pages 38923-38936 Publisher Royal Society of Chemistry Description Red blood cells or erythrocytes, constituting 40 to 45 percent of the total volume of human...
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Numerical simulation of shear-induced drug encapsulation

Authors Mehdi Nikfar, Meghdad Razizadeh, Yaling Liu Publication date 2020/11/23 Journal Bulletin of the American Physical Society Publisher American Physical Society Description Recent studies show that shear-induced drug loading methods in the microfluidic device is an efficient intracellular...
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Coarse-grained Modeling of Liposome Nano-extrusion Using Fluctuating Lattice Boltzmann Method

Authors Meghdad Razizadeh, Mehdi Nikfar, Yaling Liu Publication date 2020/11/23 Journal Bulletin of the American Physical Society Publisher American Physical Society Description K03. 00003: Coarse-grained Modeling of Liposome Nano-extrusion Using Fluctuating Lattice Boltzmann...
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Label-free detection of rare circulating tumor cells by image analysis and machine learning

Authors Shen Wang, Yuyuan Zhou, Xiaochen Qin, Suresh Nair, Xiaolei Huang, Yaling Liu Publication date 2020/7/22 Journal Scientific reports Volume 10 Issue 1 Pages 1-10 Publisher Nature Publishing Group Description Detection and characterization of rare circulating tumor cells (CTCs) in patients'...
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Coarse-Grained Modeling of Pore Dynamics on the Red Blood Cell Membrane under Large Deformations

Authors Meghdad Razizadeh, Mehdi Nikfar, Ratul Paul, Yaling Liu Publication date 2020/8/4 Journal Biophysical Journal Volume 119 Issue 3 Pages 471-482 Publisher Cell Press Description Transient pore formation on the membrane of red blood cells (RBCs) under high mechanical tensions is of great...
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Prediction of mechanical hemolysis in medical devices via a Lagrangian strain‐based multiscale model

Authors Mehdi Nikfar, Meghdad Razizadeh, Jiafeng Zhang, Ratul Paul, Zhongjun J Wu, Yaling Liu Publication date 2020/2/3 Journal Artificial Organs Description This work introduces a new Lagrangian strain‐based model to predict the shear‐induced hemolysis in biomedical devices. Current computational...
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Multiscale modeling of hemolysis during microfiltration

Authors Mehdi Nikfar, Meghdad Razizadeh, Ratul Paul, Yaling Liu Publication date 2020/4/10 Journal Microfluidics and Nanofluidics Volume 24 Issue 5 Publisher SPRINGER HEIDELBERG Description In this paper, we propose a multiscale numerical algorithm to simulate the hemolytic release of hemoglobin...
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LVHN trying cancer blood test developed by Lehigh University professor

Between CT scans in July and December, Stephen Kauffman's kidney cancer went from undetectable to widely spread in his brain, femur, liver, stomach lining and vertebrae. "All of a sudden, it's all over the place," said Kauffman, a Harleysville, Montgomery County resident. Despite advances in...
Read More

Lehigh professor develops blood test for cancer

When it comes to cancer, early detection can be the difference between life and death. Many people, however, don't find out they have cancer until they experience symptoms, and by then it's all the harder to beat. It's an unfortunate chronology that Lehigh University Professor Yaling Liu hopes to...
Read More

Simpler, High-Accuracy Method Detects Rare Circulating Tumor Cells

Metastasis―the development of tumor growth at a secondary site―is responsible for the majority of cancer-related deaths. It occurs when the primary tumor site sheds cancerous cells which are then circulated through the body via blood vessels or lymph nodes. These become seeds for eventual tumor...
Read More