Cell damage often arises when cells are transported inflow by various medical devices such as a syringe pump, artificial heart, heart valve, and bio-printer. The damage may be caused by direct contact with artificial surfaces or high shear stresses in these devices. In patients, hemolysis and platelet dysfunction resulting from blood-device interaction have been linked to renal failure, anemia, arrhythmias, stroke, and death. The goal of the proposed work is to establish multiscale computational techniques to predict the blood cell dynamics and damage in complex flow conditions, i.e., in blood-wetting biomedical devices. In conjunction with microfluidic and Couette-type blood-shearing validation systems, this integrated modeling and experimental approach will help elucidate the dynamics of blood cells in a complex flow environment and serves as a blood cell damage prediction tool for blood wetting biomedical devices. In this project, we are developing a multiscale red blood cell membrane damage model. A localized coarse-grained molecular dynamics model at the high-stress region will be concurrently linked with a network-based cellular membrane model to characterize pore formation and growth as well as to study hemoglobin release. We couple the membrane damage model with local fluid flow through the Immersed Boundary Method to study cell deformation, pore formation, and membrane rupture. Each sub-model will be validated through a series of relevant experiments using microfluidic channels. We apply the coupled model to predict cell damages under various flow conditions. A generalized cellular level blood cell damage and fluid-cell interaction model will be developed based on these simulations. Moreover, we verify the developed multiscale blood cell damage model using AFM measurements, microfluidic tests, and Couette-type blood-shearing devices. The blood cell damage model will be first validated for individual cells under controlled stress history based on hemoglobin analysis in a microfluidic system. The blood damage model will be further validated in setting up mimicking blood cell damages in the clinically relevant biomedical device by comparing the experimentally measured hemolysis produced by Couette type blood shearing devices with computational results. The developed model will finally be applied to evaluate hemolysis in a clinical circulatory assist device CentriMag.