- List the top 20 questions your team needs to answer to advance the venture forward.
- We are able to diagnose Sickle Cell Anemia, so what?
- How can we implement our project, so that it stays relevant?
- Why hasn’t an initiative for this project not yet been started?
- If our project is successful, where can we go from there?
- How will the locals react or perceive our device?
- How do we work with individuals who are unsupportive of our research?
- What can we learn from the locals that could help us with the device?
- How will their culture affect our project?
- How will our project affect their culture?
- How is our project going to change Sierra Leone?
- What are other treatment or care options if they decide not to participate?
- If this project is successful, where can we go from there?
- How will we establish the operation from one clinic to millions of clinics?
- Is this a project that we will continue providing assistance to? Or do we pass this responsibility onto the locals?
- How will the devices be distributed?
- How will we make this project affordable to the locals?
- What’s this project’s incentive for Lehigh?
- How will the locals welcome this project?
- Is there a way where we can train the locals, in order to sustain the system?
- Are there problems or aspects of the research we don’t know about?
2. Develop and Visualize the Theory of Change (Logic Model) for your venture:
Spring Semester Goals:
- Prove the detection of the HbS and HbA hemoglobin with our test strip (antibodies GS5 and GS4)
- Optimizing the amounts of antibodies, beads and running buffer for the device (cost-effectiveness in consideration)
- Prove the functionality of the Conveyor Belt with attached Syringe Pump
- Finding the optimal dimension for test strips
- Manufacturing/producing large amounts (~100) of test strips efficiently
- Complete IRB/SLA forms for Lehigh Health Valley and Sierra Leone at Lehigh (Discuss with other Sierra Leone groups)
- Receive IRB approval for obtaining HbS blood samples from the Lehigh Valley Health Network
Summer Goals (Mountaintop):
- Prepare 100+ test strips and reagents for clinical trial and demonstration purposes.
- Run shelf life experiments
- Develop interview and questionnaire questions for Sierra Leone
Sierra Leone Field Trip:
- Carry out clinical trials with locals who are confirmed as sickle cell patients through one of the programs: SCCAN or Sickle Cell Society
- Carry out interviews with recruited patients about their livelihood after being diagnosed with sickle cell (perception)
- Research for a potential Case Study publication for the Fall 2020 semester