Publications

2019

X. Frank Zhang and Xuanhong Cheng, “Platelet Mechanosensing Axis Revealed,” Nature Materials, 18 (7), 661-662 (2019).

Yi Wang, Kiely Heinz and Xuanhong Cheng, “Tangential Flow Microfiltration for Viral Separation and Concentration,” Micromachines (Basel),  10(5), 320, DOI: 10.3390/mi10050320. (2019).

Yifeng Qian, Zeng Xie, Yongkang Gao, Hang Li, Sushil Kumar, Xuanhong Cheng, Filbert Bartoli, “Intensity-modulated nanoplasmonic interferometric sensor for MMP-9 detection,” Lab on a Chip, 19(7), 1267-1276 (2019).

Yi Wang, Michael Morabito, Xiaohui F. Zhang, Edmund Webb III, Alparslan Oztekin and Xuanhong Cheng, “Shear-Induced Extensional Response Behaviors of Tethered von Willebrand Factor,” Biophysical Journal, 116(11), 2092-2102 (2019).

Marco Farina, Xin Jin, Gianluca Fabi, Eleonora Pavoni, Andrea di Donato, Davide Mencarelli, Antonio Morini, Francesco Piacenza, Richard Al Hadi, Yan Zhao, Yaqing Ning, Tiziana Pietrangelo, Xuanhong Cheng, James CM Hwang, “Inverted Scanning Microwave Microscope for in vitro Imaging and Characterization of Biological Cells,” Applied Physical Letters, 114(9), 093703 (2019).

Edmund Webb III, Chunqiao Dong, Sagar Kania, Michael Morabito, Yi Wang Xuanhong Cheng, Xiaohui F. Zhang, Alparslan Oztekin, “Multiscale Modeling of the Human Blood Protein von Willebrand Factor,” Biophysical Journal, 116(3), 323a (2019).

Xiao Ma, Hang Li, Xiaotian Du, Yaqing Ning, Vahid Gholizadeh, Cris Palego, Xuanhong Cheng and James C. M. Hwang, “Sensitivity Analysis for Ultra-wideband 2-port Impedance Spectroscopy of a Live Cell,” IEEE Journal of Electromagnetics, RF, and Microwaves in Medicine and Biology, DOI: 10.1109/JERM.2019.2921221 (2019).

Michael Morabito, Mustafa Usta, Xuanhong Cheng, Xiaohui F. Zhang, Alparslan Oztekin, and Edmund Webb III, “Prediction of Sub-Monomer A2 Domain Dynamics of the von Willebrand Factor by Random Forest Algorithm and Coarse-Grained Molecular Dynamics Simulation,” Scientific Reports, accepted (2019).

Xiaotian Du, Xiao Ma, Hang Li, , Lei Li, Xuanhong Cheng and James C. M. Hwang, “Validation of Clausius-Mossotti Function in Wideband Single-Cell Dielectrophoresis,” IEEE Journal of Electromagnetics, RF, and Microwaves in Medicine and Biology, accepted (2019).  

2018

Hang Li,  Caroline Multari, Cristiago Palego, Xiao Ma, Xiaotian Du, Yaqing Ning, Javier Buceta, James C. M. Hwang and Xuanhong Cheng, “Differentiation of Live and Heat-killed E. coli by Microwave Impedance Spectroscopy,” Sensors and Actuators B: Chemical, 255 (Part 2), 1614-1622 (2018).

Wei Wei, Chuqiao Dong, Michael Morabito, Xuanhong Cheng, X. Frank Zhang, Edmund B. Webb, and Alparslan Oztekin, “Coarse-Grain Modeling of Shear-Induced Binding beween von Willebrand Factor and Collagen,” Biophysical Journal, 114 (8), 1816-1829 (2018).

Michael Morabito, Chuqiao Dong, Wei Wei, Xuanhong Cheng, Xiaohui F. Zhang, Alparslan Oztekin, and Edmund Webb III, “Internal Tensile Force and A2 Domain Unfolding of von Willebrand Factor Multimers in Shear Flow,” Biophysical Journal, 115(10), 1860-1871 (2018).

Xiao Ma, Xiaotian Du, Hang Li, Xuanhong Cheng and James Hwang, “Ultra-wideband Impedance Spectroscopy of a Live Cell,”  IEEE Transactions on Microwave Theory and Techniques, 66 (8), 3690-3696, (2018).

Thomas M. Reidy, Danli Luo, Priyokti Rana, Brenden Huegel and Xuanhong Cheng, “Transparency of PDMS Based Microfluidic Devices under Temperature Gradients,” Journal of Micromechanics and Microengineering, 29, 015014 (2018).

Hang Li, Xiao Ma, Xiaotian Du, Lei Li, Xuanhong Cheng and James C. M. Hwang, “Correlation Between Optical Fluorescence and Microwave Transmission During Single-cell Electroporation,” IEEE Transactions on Biomedical Engineering, DOI: 10.1109/TBME.2018.2885781 (2018).

2017

Chao Zhao, Zhibo Cao, John Fraser, Alparslan Oztekin, and Xuanhong Cheng, “Optimization of nanoparticle focusing by coupling thermophoresis and engineered vortex in a microfluidic channel,” Journal of Applied Physics, 121, (2) (2017).

Hang Li, Agnese Denzi, Xiao Ma, Xiaotian Du, Yaqing Ning, Xuanhong Cheng, Francesca Apollonio, Micaela Liberti, and James C. M. Hwang, “Distributed Effect in High-Frequency Electroporation of Biological Cells,” IEEE Transactions on Microwave Theory and Techniques. 65 (9), 3503-3511 (2017).

Justin P. Jahnke, Austin M. Smith, Nicole E. Zander, Victoria Wiedorn, Kenneth E. Strawhecker, Jessica L. Terrell, Demitra N. Stratis-Cullum and Xuanhong Cheng., “Living” dynamics of filamentous bacteria on an adherent surface under hydrodynamic exposure. Biointerphases, 12 (2), 02c410 (2017).

Krissada Surawathanawises, Victoria Wiedorn and Xuanhong Cheng, “Micropatterned macroporous structures in microfluidic devices for viral separation from whole blood,” Analyst , 142 (12), 2220-2228 (2017).

2016

Bu Wang and Xuanhong Cheng, “Enhancement of Binding Kinetics on Affinity Substrates by Laser Point Heating Induced Transport,” Analyst, 141, 1807-1813 (2016).

Krissada Surawathanawises and Xuanhong Cheng, “Microfluidic Devices with Templated Regular Macroporous Structures for HIV Viral Capture,” Analyst, 141, 1669-1677 (2016).

Shunqiang Wang, Antony Thomas, Elaine Lee, Shu Yang, Xuanhong Cheng and Yaling Liu, “Highly Efficient and Selective Isolation of Rare Tumor Cells Using a Microfluidic Chip with Wavy-herringbone Micro-patterned Surfaces,” Analyst, 141, 2228-2237 (2016).

Jing Liu, Liping Pan, Xuanhong Cheng and Yevgeny Berdichevsky, “Perfused drop microfluidic device for brain slice culture-based drug discovery,” Biomedical Microdevices, 18(3), 1-10 (2016).

Lin Zhou, Kun Wang, Zhenhua Wu, Haidao Dong, Hao Sun, Xuanhong Cheng, Hong lian Zhang, Hongbo Zhou, Chunping Jia, Qinghui Jin, Hongju Mao, Jean-Luc Coll, and Jianlong Zhao, “Investigation of Controllable Nanoscale Heat-Denatured Bovine Serum Albumin Films on Graphene.” Langmuir, 32(48): 12623-12631 (2016).

Justin Jahnke, Jessica Terrell, Austin Smith, Xuanhong Cheng, Dimitra Stratis-Cullum, “Influences of Adhesion Variability on the Living Dynamics of Filamentous Bacteria in Microfluidic Channels,” Molecules, 21(8), 1-15 (2016).

2015

Agnese Denzi, Caterina Merla, Cristiano Palego, Alessandra Paffi, Yaqing Ning, Caroline R. Multari, Xuanhong Cheng, Francesca Apollonio, James C. M. Hwang, and Micaela Liberti, “Assessment of cytoplasm conductivity by nanosecond pulsed electric fields,” IEEE Trans. Biomedical Engineering, 62(6), 1595-1603 (2015).

Wenli Ouyang, Wei Wei, Xuanhong Cheng, X. Frank Zhang, Edd B. Webb III and Alp Oztekin, “Flow-induced conformational change of von Willebrand Factor multimer: Results from a molecular mechanics informed model,” Journal of Non-Newtonian Fluid Mechanics 217, 58-67 (2015).

2014

Krissada Surawathanawises and Xuanhong Cheng, “Nanoporous anodic aluminum oxide with a long-range order and tunable cell sizes by phosphoric acid anodization on pre-patterned substrates,” Electrochimica Acta, 117, 498-503 (2014).

Chao Zhao, Alparslan Oztekin and Xuanhong Cheng, “Measuring the Soret coefficient of nanoparticles in a dilute suspension,” Journal of Nanoparticle Research, 16(10), 2625_1-11 (2014)

Yaqing Ning, Caroline Multari, Xi Luo, Cristiano Palego, Xuanhong Cheng, James C. M. Hwang, Agnese Denzi, Caterina Merla, Francesca Apollonio, and Micaela Liberti, “Broadband Electrical Detection of Individual Biological Cells,” IEEE Transactions on Microwave Theory and Techniques, 62(9), 1905-1922 (2014).

Bu Wang, Sabrina Jedlicka and Xuanhong Cheng, “Neural differentiation of neural stem cells C17.2 correlated to medium availability sets design criteria in microfluidic systems,” PLOS One, 9(10):e109815 (2014).

2013

Chao Zhao, Alparslan Oztekin and Xuanhong Cheng, “Gravity-induced swirl of nanoparticles in microfluidics,” Journal of Nanoparticle Research, 15(5), 1611_1-14 (2013).

Yi Hu, Xuanhong Cheng, and H. Daniel Ou-Yang, “Enumerating virus-like particles in an optically concentrated suspension by fluorescence correlation spectroscopy,” Biomedical Optics Express, 4(9), 1646-1653 (2013).

Shu-Han Wu, Kuang-Li Lee , Arthur Chiou, Xuanhong Cheng, and Pei-Kuen. Wei, “Dynamic Cell Secretion Measured by Plasmonic Resonance in Gold Nanoslits with Cell-Trapping Microfluidic Device,” Small,  9(20), 3532-3540 (2013).

Yongkang Gao, Qiaoqiang Gan, Zeming Xin, Xuanhong Cheng and Filbert J. Bartoli, “Plasmonic interferometers for label-free multiplexed sensing,” Optics Express, 21(5), 5859-5871 (2013).

Yongkang Gao, Qiaoqiang Gan, Zeming Xin, Xuanhong Cheng and Filbert J. Bartoli, “Plasmonic interferometric sensor arrays for high-performance label-free biomolecular detection,” Lab on a Chip, 13, 4755-4764 (2013).

2012

Yonggang Gao, Qiaoqiang Gan, Zheming Xin, Xuanhong Cheng, Filbert J. Bartoli, “Plasmonic Mach–Zehnder Interferometer for Ultrasensitive On-Chip Biosensing,” ACS Nano 5(12), 9836–9844 (2012).

Alex Weldon, Pisist Kumnorkaew, Bu Wang, Xuanhong Cheng and James F. Gilchrist, “Fabrication of Macroporous Polymeric Membranes through Binary Convective Deposition,” ACS Applied Materials and Interfaces, 4(9), 4532-4540 (2012).

2011

Bu Wang, Pisist Kumnorkaew, Alex Weldon, James F. Gilchrist and Xuanhong Cheng, “Effect of Surface Nano-topography on Immunoaffinity-Based Cell Capture in Microfluidic Devices,” Langmuir, 27, (17), 11229-11237 (2011).

Chao Zhao, Xuanhong Cheng, “Microfluidic Separation of Viruses from Blood Cells Based on Intrinsic Transport Processes,”Biomicrofluidics, 5(3), 032004 (2011).

David S. Boyle, Kenneth R. Hawkins, Matthew S. Steele, Mitra Singhal and Xuanhong Cheng, “Emerging technologies for point-of-care CD4 T-lymphocyte counting,” Trends in Biotechnology, 30(1), 45-54, (2011)

Nicholas N. Watkins, Supriya Sridhar, Xuanhong Cheng, Mehmet Toner, William Rodriguez and Rashid Bashir, “A microfabricated electrical differential counter for the selective enumeration of CD4+ T lymphocytes,” Lab on a Chip11(8): 1437-1447 (2011)

2010

Xuanhong Cheng, E. Yegan Erdem, Shoji Takeuchi, Hiroyuki Fujita, Buddy D. Ratner, Karl F. Böhringer, “ Infrared Light Induced Patterning of Proteins on ppNIPAM Thermoresponsive Thin Films: a Protein Laser Printer,” Lab on a Chip, 10(8), 1079-1085 (2010)

2009

Xuanhong Cheng , Grace Chen, and William Rodriguez, “ Micro- and Nanotechnology for Viral Detection,” Analytical and Bioanalytical Chemistry, 393(2), 487-501 (2009) (Critical Review).

Xuanhong Cheng, William Rodriguez and Mehmet Toner, “An Improved Microfluidic Device for Accurate CD4 Counts at the Point of Care,” Lab on a Chip, 9(10), 1357-1364 (2009)

Murat Tunc, Umran Yildirim, Harun Yuksel, Xuanhong Cheng , Mark Humayun, Buddy Ratner, “Conjunctival Impression Cytology by Using a Thermosensitive Adhesive: Polymerised N-isoprophyl acrylamide,” Retina , 28(7), 770-773 (2009)

Liju Yang, Xuanhong Cheng , Yi-Shao Liu, Rashid Bashir, “Lab-on-a-chip Impedance Detection of Microbial and Cellular Activity”, in Methods in Bioengineering Book Series , edited by Nahmias Yaakov and Sangeeta Bhatia, Artech House, Boston, MA, 2009

2008

Murat Tunc, Mark Humayun, Xuanhong Cheng and Buddy D. Ratner, “A Reversible Thermosensitive Adhesive for Retinal Implants- In Vivo Experience with Plasma-deposited Poly(N-Isopropyl Acrylamide),”Retina-the Journal of Retinal and Vitreous Diseases , 28 (9), 1338-1343 (2008).

OLDER

Murat Tunc, Xuanhong Cheng , Buddy D. Ratner, Ellis Meng and Mark Humayun, “Reversible Thermosensitive Glue for Retinal Implants,” Retina – the Journal of Retinal and Vitreous Diseases, 27, 938-942(2007)

Xuanhong Cheng , Yi-shao Liu, Daniel Irimia, Utkan Demirci, Liju Yang, Lee Zamir, William R. Rodríguez, Mehmet Toner and Rashid Bashir , “ Cell Detection and Counting through Cell Lysate Impedance Spectroscopy in Microfluidic Devices, ” Lab on a Chip , 7, 746-755(2007).

Meiling Li, Ganga Fernando, Lorraine G. van Waasbergen, Xuanhong Cheng , Buddy D. Ratner, and Gary R. Kinsel, “Thermoresponsive MALDI Probe Surfaces as a Tool for Protein On-Probe Purification,”Analytical Chemistry , 79 , 6840 -6844(2007)

Xuanhong Cheng , Daniel Irimia, Meredith Dixon, Joshua C. Ziperstein, Utkan Demirci, Lee Zamir, Ronald G. Tompkins, Mehmet Toner, William Rodriguez, “A Microchip Approach for Practical Label-free CD4+ T Cell Counting of HIV-infected Subjects in Resource-Poor Settings ,” Journal of AIDS , 45, 257-261(2007). (Featured by MIT Tech Review).

Kenneth Kotz , Xuanhong Cheng , Mehmet Toner, “ PDMS Device Fabrication and Surface Modification,”Journal of Visualized Experiments , DOI: 10.3791/319, available at http://www.jove.com/index/Details.stp?ID=319 (2007).

Heather E. Canavan, Dan J. Graham, Xuanhong Cheng , Buddy D. Ratner and David G. Castner, “Comparison of Native Extracellular Matrix with Adsorbed Protein Films Using Mass Spectrometry,”Langmuir , 23, 50-56(2007). (Cover Image of Langmuir) .

Xuanhong Cheng , Daniel Irimia, Meredith Dixon, Kazuhiko Sekine, Utkan Demirci, Lee Zamir, Ronald G. Tompkins, William Rodriguez, Mehmet Toner, “Practical Label-free CD4+ T Cell Counting of HIV-infected Subjects: a Microchip Approach,” Lab on a Chip, 7, 170-178(2006). (Featured by Royal Society of Chemistry).

Xuanhong Cheng , Heather E. Canavan, Dan J. Graham, David G. Castner and Buddy D. Ratner, “Protein Interaction with Thermoresponsive Surfaces by Plasma Deposition,” BiointerPhases, 1, 61-72(2006).

Heather E. Canavan, Xuanhong Cheng , Dan J. Graham, Buddy D. Ratner and David G. Castner, “A Plasma-Deposited Surface for Cell Sheet Engineering: Advantages over Mechanical Dissociation of Cells,” Plasma Processes and Polymers , 3, 516-523(2006).

Heather E. Canavan, Xuanhong Cheng , Dan J. Graham, Buddy D. Ratner and David G. Castner, “Surface Characterization of the Extracellular Matrix upon Cell Detachment from a Thermoresponsive Polymer,” Langmuir , 21, 1949-1955 (2005). (Cover Image of Langmuir).

Heather E. Canavan, Xuanhong Cheng , Dan J. Graham, Buddy D. Ratner and David G. Castner, “Cell Sheet Detachment Affects the Extracellular Matrix: A Surface Science Study Comparing Thermal Lift-off, Enzymatic and Mechanical Methods,” Journal of Biomedical Materials Research Part A, 75A , 1-13 (2005).

Xuanhong Cheng , Heather E. Canavan, M. Jeanette. Wenzel, James R. Hull, Matthew S. Wagner, Sasha J. Kweskin, Rosnita A. Talib, Sally L. McArthur, Gabor A. Somorjai, David G. Castner, Buddy D. Ratner “ Characterization of the Surface Chemical and Mechanical Properties of Plasma Polymerized -isopropylacrylamide,” Langmuir, 21, 7833-7841(2005).

Xuanhong Cheng , Yanbing Wang, Yael Hanein, Karl F. Böhringer and Buddy D. Ratner, “Novel Cell Patterning Using Thermoresponsive Surface Chemistry,” Journal of Biomedical Materials Research Part A, 70A, 159-168 (2004). (SFB Outstanding Research Award).

ORIGINAL DESIGNS, PLAN, INVENTIONS AND PATENTS

Buddy D. Ratner, Xuanhong Cheng , Yanbing Wang, Yael Hanein, Ashutosh Shastry and Karl F. Böhringer, “Apparatus and Methods for Binding Molecules and Cells,” filed, OTL Ref. No.’s 2061-3773-4435PT (U.S.) & 2061-3773-4437PT (PCT), Jul. 30, 2003.

Murat Tunc, Xuanhong Cheng , Buddy D. Ratner, Ellis Meng and Mark Humayun, “Reversible Attachment of Retinal Implants, Other Implants and Drug Delivery Devices,” filed November 29, 2007, US patent application No. 60/867,668

Mehmet Toner, William Rodriguez, Xuanhong Cheng , Daniel Irimia, Meredith Dixon, Kazuhiko Sekine, Utkan Demirci, Lee Zamir, Ronald G. Tompkins, “A Microfluidic Chip for CD4+ T Cell Count Based on Flow Assisted Cell Affinity Isolation,” US patent filed, March 15, 2006, US patent application No. 60/782,470

Rashid Bashir, Mehmet Toner, Xuanhong Cheng, William Rodriguez, “ Methods for Detecting Cells and Other analytes,” US patent filed, September 15, 2008, US patent application No. 12/293,046

Daniel Ouyang and Xuanhong Cheng, “Opto-fluidic Nanoparticle Detection Apparatus,” US patent PCT Pub. No. WO2009/108921, PCT Pub. No. WO2009/108921, August 28, 2013, US patent No. 8,537,356

William Rodriguez, Aaron Oppenheimer, Rashid Bashir, Nicholas Watkins, Xuanhong Cheng, Mehmet Toner, and Grace Chen, “Methods for Counting Cells,” US patent, EP 2156376 B1

Chao Zhao, Alp Oztekin and Xuanhong Cheng, “Microfluidic Concentrator for Label-Free, Continuous Nanoparticle Processing”, US Patent App. 15/343,784

 

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