Publications

1. Krueger, E.P, and Brown, A.C. 2019. Inhibition of bacterial toxins as an anti-virulence strategy. Journal of Biological Engineering. 13(4)
2. Chang, E.H., Huang, J., Lin, Z., and Brown, A.C. 2019. Catechin-mediated restructuring of a bacterial toxin inhibits activity. BBA – General Subjects. 1863(1):191-198.
3. Nygren, P., Balashova, N.V., Brown, A.C., Kieba, I., Dhingra, A., Boesze-Battaglia, K., and Lally,E.T. 2018. Aggregatibacter actinomycetemcomitans leukotoxin causes activation of LFA-1. Cellular Microbiology. e12967.
4. Brown, A.C., Boesze-Battaglia, K., Balashova, N., Gomez, N.M., Speicher, K., Tang, H.-Y., Duszyk, M.E., and Lally, E.T. 2018. Membrane localization of the repeats-in-toxin (RTX) leukotoxin (LtxA) produced by Aggregatibacter actinomycetemcomitans. PLoS ONE. 13(10): e0205871.
5. Nice, J.B., Balashova, N.V., Kachlany, S.C., Koufos, E., Krueger, E., Lally, E.T., and Brown, A.C. 2018. Aggregatibacter actinomycetemcomitans leukotoxin is delivered to host cells in an LFA-1-independent manner when associated with outer membrane vesicles. Toxins. 10(10):414.
6. Osickova, A., Masin, J., Sulc, M. Roderova, J., Wald, T., Brown, A.C., Koufos, E., Chang, E.H., Giannakakis, A., Lally, E.T., Balashova, N., and Osicka, R. 2018. Cytotoxic activity of Kingella kingae RtxA toxin depends on post-translational acylation of lysine residues and cholesterol binding. Emerging Microbes and Infections. 7(1):178.
7. Krueger, E., Hayes, S., Chang, E.H., Yutuc, S., and Brown, A.C. 2018. Receptor-based Peptides for Inhibition of Leukotoxin Activity. ACS Infectious Diseases. 4(7):1073-1081.
8. Balashova, N., Giannakakis A., Brown, A.C., Koufos, E., Arakawa, T., Tang, H.-Y., and Lally, E.T. 2018. Generation of a recombinant Aggregatibacter actinomycetemcomitans RTX toxin in Escherichia coli. Gene. 672:106-114.
9. Rasti, E.R., Schappert, M.S., and Brown, A.C. 2018. Association of Vibrio cholerae 569B outer membrane vesicles with host cells occurs in a GM1-independent manner. Cellular Microbiology.20:e12828.
10. Koufos, E., Chang, E.H., Rasti, E.S., Krueger, E., and Brown, A.C. 2016. Use of a cholesterol recognition amino acid consensus (CRAC) peptide to inhibit binding to cholesterol by a bacterial toxin. Biochemistry. 55(34):4787-4797.
11. Brown, A.C., Koufos, E., Balashova, N.V., Boesze-Battaglia, K., and Lally, E.T. 2016. Inhibition of LtxA toxicity by blocking cholesterol binding with peptides. Molecular Oral Microbiology. 31(1):94-105. ǂThese authors contributed equally.
12. Webb, J.N., Koufos, E., and Brown, A.C. 2016. Inhibition of Bacterial Toxin Activity by the Nuclear Stain, DRAQ5. Journal of Membrane Biology. 249(4):503-511.
13. Miller, C.M., Brown, A.C., and Mittal, J.* 2014. Disorder in cholesterol-binding functionality of CRAC peptides: A molecular dynamics study. J. Phys Chem. B. 118:13169-13174.
14. Brown, A.C., Balashova, N.V., Epand, R.M., Epand, R.F., Bragin, A. Kachlany, S.C., Walters, M.J., Du, Y., Boesze-Battaglia, K., and Lally, E.T. 2013. Aggregatibacter actinomycetemcomitans leukotoxin utilizes a cholesterol recognition amino acid consensus (CRAC) site for membrane association. J. Biol. Chem. 288:23607-23621.
15. Brown, A.C., and Wrenn, S.P. 2013. Nanoscale phase separation in DSPC-Cholesterol systems. Langmuir. 29:9832-9840.
16. Walters, M.J.ǂ, Brown, A.C.ǂ, Edrington, T.C., Baranwal, S., Du, Y., Lally, E.T., and Boesze-Battaglia, K. 2013. Membrane association and destabilization by Aggregatibacter actinomycetemcomitans leukotoxin require changes in secondary structures. Mol. Oral Microbiol. 28:342-353. ǂ These authors contributed equally.
17. Brown, A.C., Boesze-Battaglia, K., Du, Y., Stefano, F.P., Kieba, I.R., Epand, R.F., Kakalis, L., Yeagle, P.L., Epand, R.M., and Lally, E.T. 2012. Aggregatibacter actinomycetemcomitans leukotoxin cytotoxicity occurs through bilayer disruption
18. Fong, K.P.ǂ, Tang, H.-Y.ǂ, Brown, A.C., Kieba, I.R., Speicher, D.W., Boesze-Battaglia, K., and Lally, E.T. 2011. Aggregatibacter actinomycetemcomitans leukotoxin is post-translationally modified by addition of either saturated or hydroxylated fatty acyl chains. Mol. Oral Microbiol. 6:1-15. ǂ These authors contributed equally.
19. Boesze-Battaglia, K., Brown, A.C., Walker, L., Besack, D., Wrenn, S.P., Krummenacher, C., and Shenker, B.J. 2009. Cytolethal distending toxin induced cell cycle arrest of lymphocytes is dependent upon recognition and binding to cholesterol. J. Biol. Chem. 284:10650-10658.
20. Brown, A.C., Wrenn, S.P., and Abedin, M.Z. 2009. Gender differences in cholesterol nucleation in bile: Estrogen is a potential contributory factor. J. Membr. Biol. 232:35-45.
21. Brown, A.C., Towles, K.B., and Wrenn, S.P. 2007. Measuring raft size as a function of membrane composition in PC-based systems: Part I – Binary systems. Langmuir. 23:11180-11187.
22. Brown, A.C., Towles, K.B., and Wrenn, S.P. 2007. Measuring raft size as a function of membrane composition in PC-based systems: Part II – Ternary systems. Langmuir. 23:11188-11196.
23. Towles, K.B., Brown, A.C., and Wrenn, S.P.DA, Dan, N. 2007. Effect of membrane microheterogeneity and domain size on fluorescence resonance energy transfer. Biophys. J.93:655-667.