There has been rising demand to isolate rare cells, such as circulating tumor cells (CTCs) at an ultralow concentration, which is critical in prognosis and early diagnosis of cancer. We designed a novel surface to significantly enhance rare cell capture efficacy. Specifically, we fabricate a hierarchical surface consisting of patterned structures at two length scales: a microscale surface of ripples or herringbone structure and an array of nanoparticles or nanopillars. By introducing a novel magnetic particle coating, active release of the captured CTC is achieved, which allows further analysis and culturing of the released CTCs. We are also involved in an on-going clinical trial with Lehigh Valley Health Networks, where blood from 20 melanoma and 30 colon tumor patients will be tested.
- S. Wang, Y. Cho, X. Cheng, S. Yang, Y. Liu, Y. Liu, “Integration of Hierarchical Micro-/Nanostructures in a Microfluidic Chip for Efficient and Selective Isolation of Rare Tumor Cells”, Micromachines, 10(10), 2019
- W. Shi, S. Wang, A. Maarouf, R. He, Y. Doruk, Y. Liu, “Magnetic Particles Assisted Capture and Release of Rare Tumor Cells using Wavy-herringbone Structured Microfluidic Devices”, Lab on a Chip, 17, 3291-3299, 2017
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