The Jagota Group

Departments of Bioengineering and of Chemical and Biomolecular Engineering at Lehigh University

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  • Research
    • Biomechanics of Viral Entry and Vesicle Exocytosis (Synaptic Transmission)
    • Hybrids of DNA and Single Wall Carbon Nanotubes
      • Machine Learning to Find SWCNT-Recognition DNA Sequences
      • Sorting SWCNTs Using Molecular Recognition by DNA
      • Molecular Simulation: Studies of DNA-SWCNT and peptide-CNT structure
      • Solution Spectroscopy Methods for SWCNT-DNA
    • Adhesion and Friction of Soft Materials
      • Film-Terminated Fibrillar Architecture : Adhesion and Friction
      • Dislocations at Patterned Soft Material Interfaces Control Adhesion and Friction
      • Tunability, Switchability, Control of Adhesion
    • Surface Stress of Soft Solids
      • Flattening Driven by Surface Stress
      • Surface Stress and Wetting
      • Surface Stress and Contact Mechanics
      • Surface Stress, Some Other Work
    • Earlier Work
      • Sintering and Compaction of Powder Packings
      • Computational Fracture Mechanics
      • Film-Terminated Fibrillar Architecture : Self-collapsed structure
      • Mechanical Properties of Laminated Glass
      • Single Molecule Force Spectroscopy: Peeling DNA from graphite and carbon nanotubes
      • CNT-based Sensors
      • Stress Measurement in Films
      • CNTs in Cells: Entry Mechanism in HUVEC Cells
      • Deposition of CNTs on Surfaces
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Sorting SWCNTs Using Molecular Recognition by DNA

Ming Zheng’s group found that certain DNA sequences recognize specific carbon nanotubes.  They have identified several hundred such special sequences.  Using these, one can separate out most SWCNT species from a mixture.  The basis for recognition, we propose, is the formation of an ordered DNA structure stabilized by the CNT core.  We have found that anti-parallel DNA strands can organize into ordered sheets similar to the beta-sheet structure of poly-peptides.  Moreover, these can be rolled into barrels that resemble the protein beta-barrels.

 

“DNA sequence motifs for structure-specific recognition and separation of carbon nanotubes”, Xiaomin Tu, Suresh Manohar, Anand Jagota, Ming Zheng, Nature v 460 250-253 (2009).

 

Ao, Geyou, Constantine Y. Khripin, and Ming Zheng. “DNA-controlled partition of carbon nanotubes in polymer aqueous two-phase systems.” Journal of the American Chemical Society 136, no. 29 (2014): 10383-10392.

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