The Jagota Group

Departments of Bioengineering and of Chemical and Biomolecular Engineering at Lehigh University

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  • Research
    • Biomechanics of Viral Entry and Vesicle Exocytosis (Synaptic Transmission)
    • Hybrids of DNA and Single Wall Carbon Nanotubes
      • Machine Learning to Find SWCNT-Recognition DNA Sequences
      • Sorting SWCNTs Using Molecular Recognition by DNA
      • Molecular Simulation: Studies of DNA-SWCNT and peptide-CNT structure
      • Solution Spectroscopy Methods for SWCNT-DNA
    • Adhesion and Friction of Soft Materials
      • Film-Terminated Fibrillar Architecture : Adhesion and Friction
      • Dislocations at Patterned Soft Material Interfaces Control Adhesion and Friction
      • Tunability, Switchability, Control of Adhesion
    • Surface Stress of Soft Solids
      • Flattening Driven by Surface Stress
      • Surface Stress and Wetting
      • Surface Stress and Contact Mechanics
      • Surface Stress, Some Other Work
    • Earlier Work
      • Sintering and Compaction of Powder Packings
      • Computational Fracture Mechanics
      • Film-Terminated Fibrillar Architecture : Self-collapsed structure
      • Mechanical Properties of Laminated Glass
      • Single Molecule Force Spectroscopy: Peeling DNA from graphite and carbon nanotubes
      • CNT-based Sensors
      • Stress Measurement in Films
      • CNTs in Cells: Entry Mechanism in HUVEC Cells
      • Deposition of CNTs on Surfaces
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CNTs in Cells: Entry Mechanism in HUVEC Cells

With the group of Dev Mukhopadhyay at Mayo Clinic, we studied how DNA-coated CNTs enter HUVEC cells. The main conclusion is that the mechanism is actin-mediated pinocytosis.

Bhattacharya, Santanu, Daniel Roxbury, Xun Gong, Debabrata Mukhopadhyay, and Anand Jagota. “DNA conjugated SWCNTs enter endothelial cells via Rac1 mediated macropinocytosis.” Nano letters 12, no. 4 (2012): 1826-1830.

 

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